UE481521三氯化六氨合钴10534-89-1现货

适用于DNA缩合研究、诱导DNA从B型向A型或Z型转化、核酸晶体生长诱导、三级tRNA相互作用的稳定性、连接缓冲液的制备。

Cobalt (III) hexammine has been proposed as an analog of fully-solvated magnesium .This is based largely on a geometric similarity, although studies have shown that cobalt (III) hexammine is capable of activating some enzymes which usually require magnesium. Cobalt (III) hexammine has been used extensively in several types of study: to induce the B→A form and B→Z form transitions in DNA, for inducing nucleic acid crystal growth, for DNA condensation studies, and for inducing structural changes in DNA four-way junctions. Cobalt (III) hexammine has also been observed to stabilize the tertiary interactions of tRNAs. Using NMR, Robinson and Wang observed nuclear Overhausser effect (NOE) cross-peaks between the cobalt (III) hexammine amine protons and guanosine H8, imino, and cytosine amino protons of DNA, demonstrating that NMR could be used to precisely locate a metal ion complex within a specific ion-binding site.